Overview
IOT is a fairly straight-forward interface, with a few things to note.
Most IOT designs use the BRS request to determine the optimal base curve to use. The exception are the Camber designs, where IOT will provide base curve charts; these must be set up in Rx-Universe and the lens style(s) set to use the Camber chart.
IOT does support the use of blocked prism, so they will send back the KPRV? labels in the LMS file. If blocking prism is not desired, be sure to set the "Blocker maximum prism" field on the "DS" record for IOT to 0, to suppress this.
Camber Designs
The Camber designs require a few things to be set differently.
First, Camber designs do not use BRS request, but rather base curve charts which are provided by IOT. These charts must be set up in Rx-Universe by the lab, and the lens style set to use the appropriate chart. For example, if the chart is set up using chart "CA", then the lens style must be set to use that chart; on the lens style General tab:
Second, the donor blanks (pucks) used for Camber designs have aspheric, degressive-style front surfaces. IOT allows them to be blocked either upside-down, or in a "default" setting. When using Rx-Universe, they should be blocked "upside-down", the same as a progressive would be (with the add portion of the blank "up" on the blocker).
Third, the Camber designs use VCA labels to identify whether the lens is photochromatic, or polarized, and what color the lens is. If using an older implementation of IOT, it is possible these labels might not be in the list of labels sent to the calculator from Rx-Universe. This can be easily changed by modifying the LDI file for IOT to include PHOTO and POLAR. Please see the section on Use of LDI (initialization files) with Digital Vendors for more information on this.
Lenticularization / Edge Blending
IOT has the option of allowing many designs to be "lenticularized", where the lab can specify a bowl size, in which the design is "true", and outside of the diameter, the lens is "blended" to minimize the thickness.
If the design has "_L" anywhere in the LNAM (on the digital tab), then the field "Blend Diam / Bowl Size" can be set on the F12 screen in order entry. 
In the above example, the progressive design would be cut into a 40mm bowl, and the lens outside of that 40mm bowl would be "blended" to minimize thickness in the finished product.
a fairly straight-forward interface, with a few things to note.