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The program is called ACURCL.EXE and is located in the RxUniverse\RUN8 folder.  Run the program, and go to the Services tab.  You should see a screen similar to the following:
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If there is no service listed as listening on port 5640, one needs to be created.  In this case, click "New" and create an entry similar to the following:
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In the entry for the port, the configuration file specifies where the runtime and other information is, when a request is received on the port.

The ACURCL.CFG file, located (as above) in the C:\RxUniverse\etc folder, needs to contain four lines, as follows (it may contain additional comment lines, but these three lines are the critical parameters):

ACCESS-FILE                 c:\rxuniverse\etc\acuaccess
SERVER_ALIAS_FILE    c:\rxuniverse\etc\acurcl.ini
DEFAULT-USER             omics

The first specifies how access will be granted to Rx-Universe programs and files; this "acuaccess" file must exist in the specified folder, and should be set up as follows:
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The ALIAS file describes what program should be run when the thin client session connects with a certain name (or alias).  The only alias generally used by Rx-Universe is "rxuniverse", and it should be set similar to the following: